Macrophages induce gingival destruction via Piezo1-mediated MMPs-degrading collagens in periodontitis

Front Immunol. 2023 May 16:14:1194662. doi: 10.3389/fimmu.2023.1194662. eCollection 2023.

Abstract

Macrophages are an integral part of the innate immune response in periodontal tissue and play a crucial role in the progression of periodontitis. Here we reported that macrophages also provoke periodontitis-induced gingival destruction through Piezol-mediated collagen degradation. We discovered that the PIEZO1 expression was markedly elevated in patients with periodontitis through transcriptomic profiling. Moreover, Piezo1 promoted macrophage polarization toward the M1 type in response to lipopolysaccharide (LPS) and induced production of proinflammatory cytokines, which in turn stimulated production of matrix metalloproteinases (MMPs) leading to collagen degradation. Our study suggests that Piezol might be a potential therapeutic target for treating periodontitis-induced gingival destruction.

Keywords: Piezo1; gingival destruction; macrophage; matrix metalloproteinases; periodontitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Collagen / metabolism
  • Gingiva* / metabolism
  • Humans
  • Ion Channels / metabolism
  • Macrophages / metabolism
  • Matrix Metalloproteinases / metabolism
  • Periodontitis* / metabolism

Substances

  • Matrix Metalloproteinases
  • Collagen
  • PIEZO1 protein, human
  • Ion Channels

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant number 82170993) and the International Science and Technology Cooperation Program of China (grant number 2018YFE0194100).