An insight into novel therapeutic potentials of taxifolin

Yang Liu; Xiaolu Shi; Ye Tian; Shaobo Zhai; Yuyan Liu; Zhengrong Xiong; Shunli Chu

doi:10.3389/fphar.2023.1173855

An insight into novel therapeutic potentials of taxifolin

Front Pharmacol. 2023 May 12:14:1173855. doi: 10.3389/fphar.2023.1173855. eCollection 2023.

Authors

Yang Liu¹, Xiaolu Shi¹, Ye Tian¹, Shaobo Zhai¹, Yuyan Liu², Zhengrong Xiong³, Shunli Chu¹

Affiliations

¹ Department of Implantology, Hospital of Stomatology, Jilin University, Changchun, China.
² Department of Endodontics, Hospital of Stomatology, Jilin University, Changchun, China.
³ Polymer Composites Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences (CAS), Changchun, China.

Abstract

Taxifolin is a flavonoid compound, originally isolated from the bark of Douglas fir trees, which is often found in foods such as onions and olive oil, and is also used in commercial preparations, and has attracted the interest of nutritionists and medicinal chemists due to its broad range of health-promoting effects. It is a powerful antioxidant with excellent antioxidant, anti-inflammatory, anti-microbial and other pharmacological activities. This review focuses on the breakthroughs in taxifolin for the treatment of diseases from 2019 to 2022 according to various systems of the human body, such as the nervous system, immune system, and digestive system, and on the basis of this review, we summarize the problems of current research and try to suggest solutions and future research directions.

Keywords: anti-inflammation; antioxidant; chemotherapeutics; flavonoids; taxifolin.

Publication types

Review

Grants and funding

Financial support from the Scientific Research Project of Jilin Provincial Department of Education, China (JJKH20231291KJ), and the Science and Technology Development Plan of Jilin Province supports the project, China (20230203065SF).