Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Huize Chen; Chujun Deng; Zeyu Meng; Shengxi Meng

doi:10.3389/fendo.2023.956772

Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Front Endocrinol (Lausanne). 2023 May 16:14:956772. doi: 10.3389/fendo.2023.956772. eCollection 2023.

Authors

Huize Chen¹, Chujun Deng¹, Zeyu Meng², Shengxi Meng¹

Affiliations

¹ Department of Traditional Chinese Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² The Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, China.

Abstract

Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease characterized by menstrual disorders, infertility, and obesity, often accompanied by insulin resistance and metabolic disorders. The pathogenesis of PCOS is relatively complex and has a certain relationship with endocrine disorders. The increase of androgen and luteinizing hormone (LH) is the main cause of a series of symptoms. Traditional Chinese medicine (TCM) has obvious advantages and significant curative effects in the treatment of this disease. It can effectively reduce the insulin level of PCOS patients, regulate lipid metabolism, and increase ovulation rate and pregnancy rate and has fewer side effects. This article reviews the efficacy and safety of Chinese herbs and other TCM (such as acupuncture) in the treatment of PCOS and its complications in recent years, as well as the effect and mechanism on cellular endocrine, in order to provide a new clinical idea for the treatment of PCOS.

Keywords: TCM; cellular endocrinology; mechanism of action; metabolic disorders; polycystic ovary syndrome.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acupuncture Therapy*
Female
Humans
Insulin Resistance*
Medicine, Chinese Traditional
Polycystic Ovary Syndrome* / metabolism
Pregnancy
Pregnancy Rate

Grants and funding

This work was supported by the COVID-19 Emergency Response Project of Shanghai Sixth People's Hospital in 2022 (ynxg202218), Shanghai Sixth People's Hospital Medical Service Level Improvement Project Clinical Medical Technical Backbone Team Cultivation Project (20220213); Three-year Action Plan (2021-2023) of Shanghai Municipality for Further Accelerating the Inheritance, Innovation, and Development of Traditional Chinese Medicine [grant number: ZY(2021-2023)-0205-04]; Construction of East China Area and Municipal TCM Specialist Disease Alliance [grant number: ZY(2021-2023)-0302]; Provincial General Project of Innovation and Entrepreneurship training Program for College students in Heilongjiang Province (S202210228075).