Disulfidptosis: a new form of programmed cell death

J Exp Clin Cancer Res. 2023 May 31;42(1):137. doi: 10.1186/s13046-023-02712-2.

Abstract

Disulfidptosis, a new form of cell death triggered by disulfide stress, is characterized by the collapse of cytoskeleton proteins and F-actin due to the intracellular accumulation of disulfides. This discovery will eventually aid in the development of therapeutic strategies against cancer.

Publication types

  • Letter

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Actins* / metabolism
  • Apoptosis*
  • Cell Death
  • Cytoskeletal Proteins / metabolism
  • Humans

Substances

  • Actins
  • Cytoskeletal Proteins