A Web-Based Method for the Identification of IL6-Based Immunotoxicity in Vaccine Candidates

Anjali Dhall; Sumeet Patiyal; Neelam Sharma; Salman Sadullah Usmani; Gajendra P S Raghava

doi:10.1007/978-1-0716-3239-0_22

A Web-Based Method for the Identification of IL6-Based Immunotoxicity in Vaccine Candidates

Methods Mol Biol. 2023:2673:317-327. doi: 10.1007/978-1-0716-3239-0_22.

Authors

Anjali Dhall^#¹, Sumeet Patiyal^#¹, Neelam Sharma¹, Salman Sadullah Usmani¹, Gajendra P S Raghava²

Affiliations

¹ Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India.
² Department of Computational Biology, Indraprastha Institute of Information Technology, New Delhi, India. raghava@iiitd.ac.in.

^# Contributed equally.

PMID: 37258924
DOI: 10.1007/978-1-0716-3239-0_22

Abstract

Interleukin 6 (IL6) is a major pro-inflammatory cytokine that plays a pivotal role in both innate and adaptive immune responses. In the past, a number of studies reported that high level of IL6 promotes the proliferation of cancer, autoimmune disorders, and cytokine storm in COVID-19 patients. Thus, it is extremely important to identify and remove the antigenic regions from a therapeutic protein or vaccine candidate that may induce IL6-associated immunotoxicity. In order to overcome this challenge, our group has developed a computational tool, IL6pred, for discovering IL6-inducing peptides in a vaccine candidate. The aim of this chapter is to describe the potential applications and methodology of IL6pred. It sheds light on the prediction, designing, and scanning modules of IL6pred webserver and standalone package ( https://webs.iiitd.edu.in/raghava/il6pred/ ).

Keywords: Cytokines; IL6-inducing peptides; Immunotoxicity; Therapeutic peptides; Vaccine candidate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / prevention & control
Cytokines / metabolism
Humans
Interleukin-6 / genetics
Internet
Vaccines*

Substances

Interleukin-6
Cytokines
Vaccines