Macrophage polarization in bone implant repair: A review

Zhengzheng Song; Yuxi Cheng; Minmin Chen; Xiaoli Xie

doi:10.1016/j.tice.2023.102112

Macrophage polarization in bone implant repair: A review

Tissue Cell. 2023 Jun:82:102112. doi: 10.1016/j.tice.2023.102112. Epub 2023 May 20.

Authors

Zhengzheng Song¹, Yuxi Cheng¹, Minmin Chen², Xiaoli Xie³

Affiliations

¹ Central South University Xiangya Stomatological Hospital, Central South University, Changsha 410078, Hunan, China; Xiangya School of Stomatology, Central South University, Changsha 410008, Hunan, China.
² Central South University Xiangya Stomatological Hospital, Central South University, Changsha 410078, Hunan, China. Electronic address: cmm@xykqyy.net.
³ Central South University Xiangya Stomatological Hospital, Central South University, Changsha 410078, Hunan, China; Hunan Key Laboratory of Oral Health Research, Changsha 410008, Hunan, China. Electronic address: xiexiaoli@csu.edu.cn.

PMID: 37257287
DOI: 10.1016/j.tice.2023.102112

Abstract

Macrophages (MΦ) are highly adaptable and functionally polarized cells that play a crucial role in various physiological and pathological processes. Typically, MΦ differentiate into two distinct subsets: the proinflammatory (M1) and anti-inflammatory (M2) phenotypes. Due to their potent immunomodulatory and anti-inflammatory properties, MΦ have garnered significant attention in recent decades. In the context of bone implant repair, the immunomodulatory function of MΦ is of paramount importance. Depending on their polarization phenotype, MΦ can exert varying effects on osteogenesis, angiogenesis, and the inflammatory response around the implant. This paper provides an overview of the immunomodulatory and inflammatory effects of MΦ polarization in the repair of bone implants.

Keywords: Angiogenesis; Bone implant; Macrophage; Osteogenesis.

Publication types

Review

MeSH terms

Cell Differentiation
Macrophages*
Osteogenesis*
Phenotype