Association of ambient PM1 exposure with maternal blood pressure and hypertensive disorders of pregnancy in China

Man Zhang; Bo-Yi Yang; Yuqin Zhang; Yongqing Sun; Ruixia Liu; Yue Zhang; Shaofei Su; Enjie Zhang; Xiaoting Zhao; Gongbo Chen; Qizhen Wu; Lixin Hu; Yunting Zhang; Lebing Wang; Yana Luo; Xiaoxuan Liu; Jiaxin Li; Sihan Wu; Xin Mi; Wangjian Zhang; Guanghui Dong; Chenghong Yin; Wentao Yue

doi:10.1016/j.isci.2023.106863

Association of ambient PM₁ exposure with maternal blood pressure and hypertensive disorders of pregnancy in China

iScience. 2023 May 12;26(6):106863. doi: 10.1016/j.isci.2023.106863. eCollection 2023 Jun 16.

Authors

Man Zhang¹, Bo-Yi Yang², Yuqin Zhang³, Yongqing Sun⁴, Ruixia Liu¹, Yue Zhang¹, Shaofei Su¹, Enjie Zhang¹, Xiaoting Zhao¹, Gongbo Chen⁵, Qizhen Wu², Lixin Hu², Yunting Zhang², Lebing Wang², Yana Luo², Xiaoxuan Liu², Jiaxin Li², Sihan Wu², Xin Mi², Wangjian Zhang³, Guanghui Dong², Chenghong Yin⁴, Wentao Yue¹

Affiliations

¹ Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
² Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Guangdong Provincial Engineering Technology Research Center of Environmental and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
³ Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
⁴ Prenatal Diagnosis Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing 100026, China.
⁵ Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.

Abstract

Evidence concerning PM₁ exposure, maternal blood pressure (BP), and hypertensive disorders of pregnancy (HDP) is sparse. We evaluated the associations using 105,063 participants from a nationwide cohort. PM₁ concentrations were evaluated using generalized additive model. BP was measured according to the American Heart Association recommendations. Generalized linear mixed models were used to assess the PM₁-BP/HDP associations. Each 10 μg/m³ higher first-trimester PM₁ was significantly associated with 1.696 mmHg and 1.056 mmHg higher first-trimester SBP and DBP, and with 11.4% higher odds for HDP, respectively. The above associations were stronger among older participants (> 35 years) or those educated longer than 17 years or those with higher household annual income (> 400,000 CNY). To conclude, first-trimester PM₁ were positively associated with BP/HDP, which may be modified by maternal age, education level, and household annual income. Further research is warranted to provide more information for both health management of HDP and environmental policies enactment.

Keywords: Environmental health; Environmental medicine; Environmental science.