Development of a General Procedure To Access Recoverable Solid-Supported Photocatalysts for Use in Organic Synthesis

J Org Chem. 2023 Jul 7;88(13):8709-8713. doi: 10.1021/acs.joc.3c00588. Epub 2023 May 30.

Abstract

The often high cost of bespoke transition-metal-containing and organic photocatalysts inspires the development of a practical and green method by which photocatalysts can be recovered and reused through multiple reaction iterations. Herein, we showcase a general method to access novel solid-supported photocatalysts (SSPCs) that are recoverable by simple filtration. Proof-of-concept SSPCs were successfully utilized in two representative photoredox-catalyzed transformations with recycled catalysts showing no loss in activity in iterative reaction runs. Additionally, the viability of one of these SSPCs in a multi-gram scale reaction was demonstrated with the development of an easily replicated flow system.