Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology

Weiwei Liu; Ruze Ma; Chen Sun; Yingxi Xu; Yang Liu; Jiajin Hu; Yanan Ma; Difei Wang; Deliang Wen; Yang Yu

doi:10.1016/j.smrv.2023.101789

Implications from proteomic studies investigating circadian rhythm disorder-regulated neurodegenerative disease pathology

Sleep Med Rev. 2023 Aug:70:101789. doi: 10.1016/j.smrv.2023.101789. Epub 2023 May 15.

Authors

Weiwei Liu¹, Ruze Ma², Chen Sun³, Yingxi Xu¹, Yang Liu¹, Jiajin Hu¹, Yanan Ma⁴, Difei Wang⁵, Deliang Wen⁶, Yang Yu⁷

Affiliations

¹ Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China.
² Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China; Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.
³ Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China; Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China.
⁴ Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China; Department of Epidemiology and Health Statistics, School of Public Health, China Medical University, Shenyang, 110122, Liaoning, China.
⁵ Department of Gerontology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.
⁶ Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China. Electronic address: dlwen@cmu.edu.cn.
⁷ Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China. Electronic address: yyu90@cmu.edu.cn.

PMID: 37253318
DOI: 10.1016/j.smrv.2023.101789

Abstract

Neurodegenerative diseases (NDs) affect 15% of the world's population and are becoming an increasingly common cause of morbidity and mortality worldwide. Circadian rhythm disorders (CRDs) have been reported to be involved in the pathogenic regulation of various neurologic diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis. Proteomic technology is helpful to explore treatment targets for CRDs in patients with NDs. Here, we review the key differentially expressed (DE) proteins identified in previous proteomic studies investigating NDs, CRDs and associated models and the related pathways identified by enrichment analysis. Furthermore, we summarize the advantages and disadvantages of the above studies and propose new proteomic technologies for the precise study of circadian disorder-mediated regulation of ND pathology. This review provides a theoretical and technical reference for the precise study of circadian disorder-mediated regulation of ND pathology.

Keywords: Biomarker; Circadian rhythm disorder; Neurodegenerative diseases; Proteomics; Sleep disruption.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease*
Chronobiology Disorders*
Circadian Rhythm / genetics
Humans
Neurodegenerative Diseases*
Parkinson Disease* / metabolism
Proteomics