Central precocious puberty in Prader-Willi syndrome: a narrative review

Front Endocrinol (Lausanne). 2023 May 8:14:1150323. doi: 10.3389/fendo.2023.1150323. eCollection 2023.

Abstract

Prader-Willi syndrome (PWS, OMIM176270) is a rare genetic disorder with recognizable dysmorphic features and multisystemic consequences such as endocrine, neurocognitive and metabolic ones. Although most patients with Prader-Willi syndrome exhibit hypogonadotropic hypogonadism, there is variability regarding sexual maturation, with precocious puberty occurring in rare cases. Our aim is to elaborate a thorough review of Prader-Willi patients with central precocious puberty, in order to raise awareness of such cases and to enhance our knowledge regarding the diagnosis and prompt treatment of this particular PWS patients.

Keywords: Prader-Willi syndrome; endocrine; genetic; metabolic; precocious puberty.

Publication types

  • Review

MeSH terms

  • Humans
  • Hypogonadism* / complications
  • Hypogonadism* / diagnosis
  • Knowledge
  • Prader-Willi Syndrome* / complications
  • Prader-Willi Syndrome* / diagnosis
  • Puberty, Precocious* / diagnosis
  • Puberty, Precocious* / etiology
  • Sexual Maturation