Dose-response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

Yongcheng Ren; Lulu Cheng; Ranran Qie; Minghui Han; Lingzhen Kong; Wei Yan; Zheng Li; Yiduo Li; Yicun Lei

doi:10.3389/fendo.2023.1187381

Dose-response association of Chinese visceral adiposity index with comorbidity of hypertension and diabetes mellitus among elderly people

Front Endocrinol (Lausanne). 2023 May 12:14:1187381. doi: 10.3389/fendo.2023.1187381. eCollection 2023.

Authors

Yongcheng Ren^{1

2

3}, Lulu Cheng², Ranran Qie⁴, Minghui Han⁵, Lingzhen Kong², Wei Yan², Zheng Li¹, Yiduo Li¹, Yicun Lei¹

Affiliations

¹ Institute of Health Data Management, Huanghuai University, Zhumadian, He'nan, China.
² Affiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, He'nan, China.
³ Jiyuan Center for Disease Control and Prevention, Jiyuan, He'nan, China.
⁴ Department of Cancer Prevention and Control, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.

Abstract

Background: Chinese visceral adiposity index (CVAI) is a reliable indicator of visceral obesity, but little is known about the association of CVAI with comorbidity of hypertension (HTN) and diabetes mellitus (DM). This study aimed to explore the associations of CVAI with HTN-DM comorbidity, HTN or DM, HTN, and DM in elderly people and evaluate the mediating role of insulin resistance in the associations.

Methods: A total of 3,316 Chinese participants aged ≥60 years were included in this cross-sectional study. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose-response associations. Mediation analyses were used to assess the mediating effect of triglyceride-glucose (TyG) index in the associations.

Results: The prevalence rate of HTN-DM comorbidity, HTN or DM, HTN, and DM was 13.78%, 72.26%, 67.16%, and 18.88%, respectively. Linear associations between CVAI and HTN-DM comorbidity, HTN or DM, HTN, and DM were found, and ORs (95%CIs) were 1.45 (1.30-1.61), 1.39 (1.28-1.52), 1.36 (1.25-1.48), and 1.28 (1.16-1.41) for per SD increase in CVAI. Compared with quartile 1 of CVAI, the risk of HTN-DM comorbidity, HTN or DM, HTN, and DM increased 190%, 125%, 112%, and 96% for quartile 4. In addition, we found TyG index playing a key role in the associations of CVAI with HTN-DM comorbidity, HTN or DM, and DM.

Conclusion: CVAI is linearly and positively correlated with HTN-DM comorbidity, HTN or DM, HTN, and DM. The potential mechanism is insulin resistance largely mediating the associations.

Keywords: Chinese visceral adiposity index; comorbidity; elder people; insulin resistance; mediation analysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adiposity
Aged
Comorbidity
Cross-Sectional Studies
Diabetes Mellitus* / epidemiology
East Asian People
Humans
Hypertension* / complications
Hypertension* / epidemiology
Insulin Resistance*
Obesity, Abdominal / complications
Obesity, Abdominal / epidemiology

Grants and funding

This study was supported by the National Natural Science Foundation of China (grant no. 82103935) and Henan Province Science and Technology Project (grant no. 232102310497).