Baseline neurocognitive dysfunction is ubiquitous in intrinsic brain tumors- results from a large Indian cohort of patients and analysis of factors associated with domain-specific dysfunction

Aliasgar Moiyadi; Kanchi Jain; Prakash Shetty; Vikas Kumar Singh; Keerthi Radhakrishnan; Pallavi Rane; Parthiban Velayutham

doi:10.1016/j.wnsx.2023.100210

Baseline neurocognitive dysfunction is ubiquitous in intrinsic brain tumors- results from a large Indian cohort of patients and analysis of factors associated with domain-specific dysfunction

World Neurosurg X. 2023 May 9:19:100210. doi: 10.1016/j.wnsx.2023.100210. eCollection 2023 Jul.

Authors

Aliasgar Moiyadi^{1

2}, Kanchi Jain^{1

2}, Prakash Shetty^{1

2}, Vikas Kumar Singh^{1

2}, Keerthi Radhakrishnan^{1

2}, Pallavi Rane³, Parthiban Velayutham^{1

2}

Affiliations

¹ Neurosurgical Oncology Services, Dept of Surgical Oncology, Tata Memorial Centre, Mumbai, 400012, India.
² Department of Health Sciences, Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, 400094, India.
³ Clinical Research Secretariat, ACTREC, Tata Memorial Centre, Mumbai, 400012, India.

Abstract

Background: Neurocognitive function (NCF) before surgery is an important marker of baseline performance in patients with brain tumors. Increasingly, neurocognitive deficits (NCD) have been demonstrated in a high proportion of patients. Selection bias (patient, tumor, and surgical procedure related) may influence the prevalence and type of domains involved in patients with gliomas.

Methods: We evaluated baseline NCF in a consecutive cohort of intra-axial tumors in Indian patients (n = 142). A comprehensive battery evaluating five domains - attention & executive function (EF), memory, language, visuospatial function and visuomotor abilities was used. Deficits were categorized as severe and mild-moderate. Factors associated with severe NCD were evaluated.

Results: Severe NCD was present in 90% of the patients, 70% of them having affection of at least 2 domains. Attention-EF, memory and visuomotor speed were most affected. 132 underwent surgery (69 awake, 63 under general anesthesia - GA). The awake cohort had younger patients with lower grade gliomas and more left sided tumors. Multi-domain dysfunction was seen almost equally in awake/GA groups as well as left/right sided tumors. On multivariate analysis, older age, lower educational status and larger tumor volume adversely affected NCF in many of the domains. Only language dysfunction was location specific (temporal lobe tumors) though not laterality (left/right) specific.

Conclusions: NCD were seen in a large majority of cases before surgery, including those undergoing awake surgery. Language may be affected even in tumors in the non-dominant hemisphere. Attention-EF and memory are most affected and need to be factored in while assessing patient performance intraoperatively during awake surgery as well as tailoring rehabilitative measures subsequently.

Keywords: Baseline; Brain tumors; Gliomas; Neurocognition; Preoperative.