Prevalence of metabolic syndrome in adolescents based on three diagnostic definitions: a cross-sectional study

Arch Endocrinol Metab. 2023 May 25;67(5):e000634. doi: 10.20945/2359-3997000000634.

Abstract

Objective: There is no consensus as to the best criterion for the evaluation of metabolic syndrome (MS), impairing the estimation of its prevalence. This study aims to compare MS estimates using three recommended definitions for adolescents based on a cross-sectional study nested in the Consortium of Brazilian Birth Cohorts in São Luís, Maranhão.

Subjects and methods: A total of 2,515 adolescents aged between 18 and 19 years were evaluated. The criteria of International Diabetes Federation (IDF) and National Cholesterol Education Program Panel III (NCEP-ATP) modified by Cook and cols. (2003) and De Ferranti and cols. (2004) defined SM. To compare the estimates of MS prevalence, the chi-square, Fisher´s exact and Cohen´s Kappa index tests were used.

Results: Among the 2,064 participants evaluated in the final sample. The prevalence of MS ranged from 4.2% (95% CI: 3.3-5.1) to 10.2% (95% CI: 8.8-11.4). When comparing the estimates of MS prevalence in the total sample and by sex, a statistically significant difference was observed. The agreement between the criteria ranged from 0.42 (CI 95%: 0.35-0.49) to 0.55 (CI 95%: 0.48-0.62) in the total sample, 0.33 (CI 95%: 0.24-0.42) to 0.59 (95%CI: 0.47-0.71) among boys and 0.39 (95% CI: 0.26-0.52) to 0.54 (95% CI: 0.44-0.64) among girls.

Conclusion: Different criteria provide different estimates for the prevalence of MS in adolescents, reflecting the importance of establishing a consensus.

Keywords: Adolescents; Metabolic syndrome; cardiometabolic risk factors.

MeSH terms

  • Adolescent
  • Adult
  • Brazil / epidemiology
  • Cross-Sectional Studies
  • Diabetes Mellitus*
  • Female
  • Humans
  • Male
  • Metabolic Syndrome* / diagnosis
  • Metabolic Syndrome* / epidemiology
  • Prevalence
  • Risk Factors
  • Young Adult

Grants and funding

Department of Science and Technology of the Ministry of Health (DECIT) with resources transferred by the National Council for Scientific and Technological Development (CNPq; process n°: 400943/2013-1).