[Activation-induced cytidine deaminase (AID) involved in the regulation of B cell immune senescence]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2023 May;39(5):474-478.
[Article in Chinese]

Abstract

The humoral immune response of B cells is the key to the protection of specific immunity, and immune aging reshapes its production and function. The decreased B cell immune function is an indicator of immune senescence. The impaired humoral immune function mediated by antibody secreted by B cells leads to a decline in the response of elderly individuals to the vaccine. These people are therefore more susceptible to infection and deterioration, and have a higher incidence of tumors and metabolic diseases. Activation-induced cytidine deaminase (AID) is an enzyme that triggers immunoglobulin class conversion recombination (CSR) and somatic high frequency mutation (SHM). It decreases during immune senescence and is considered to be a biomarker of decreased B cell function in aging mice and humans. Understanding the inherent defects of B-cell immune senescence and the regulation mechanism of AID in the aging process can provide new research ideas for the susceptibility, prevention and treatment of diseases in the elderly.

Publication types

  • English Abstract

MeSH terms

  • Aging / metabolism
  • Animals
  • B-Lymphocytes / metabolism
  • Cytidine Deaminase* / genetics
  • Cytidine Deaminase* / metabolism
  • Humans
  • Mice
  • Somatic Hypermutation, Immunoglobulin*

Substances

  • Cytidine Deaminase
  • AICDA (activation-induced cytidine deaminase)