CuFe2O4@SiO2@L-arginine@Cu(I) as a new magnetically retrievable heterogeneous nanocatalyst with high efficiency for 1,4-disubstituted 1,2,3-triazoles synthesis

Fatemeh Salehzadeh; Maryam Esmkhani; Mahsa Zallaghi; Shahrzad Javanshir; Mohammad G Dekamin

doi:10.1038/s41598-023-36012-8

CuFe₂O₄@SiO₂@L-arginine@Cu(I) as a new magnetically retrievable heterogeneous nanocatalyst with high efficiency for 1,4-disubstituted 1,2,3-triazoles synthesis

Sci Rep. 2023 May 29;13(1):8675. doi: 10.1038/s41598-023-36012-8.

Authors

Fatemeh Salehzadeh¹, Maryam Esmkhani¹, Mahsa Zallaghi¹, Shahrzad Javanshir², Mohammad G Dekamin¹

Affiliations

¹ Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.
² Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran. shjavan@iust.ac.ir.

Abstract

A novel magnetic heterogeneous catalyst was synthesized through the immobilization of copper ions onto the l-arginine functionalized CuFe₂O₄@SiO₂. The prepared catalyst was characterized by Fourier Transform Infrared (FT-IR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM), Transmission electron microscopy (TEM), and Energy Dispersive X-Ray spectroscopy (EDX). The resulting catalyst was used in the ultrasonic-assisted synthesis of 1,2,3-triazoles via a one-pot three-component reaction of alkynes, alkyl halides, and sodium azides under green conditions within a short time. The catalyst reusability was investigated after five cycles and no significant loss of activity was observed.