Impact of Minimally Invasive Intrathoracic Hand-sewn Esophago-gastric Anastomosis in Esophagectomy for Cancer

Alexandros Charalabopoulos; Spyridon Davakis; Panagiotis Sakarellos; Efstratia Mpaili; Eleni Sarlani; Stratigoula Sakellariou; Dimitrios Ziogas; Maria Theochari; Theodoros Liakakos

doi:10.21873/anticanres.16442

Impact of Minimally Invasive Intrathoracic Hand-sewn Esophago-gastric Anastomosis in Esophagectomy for Cancer

Anticancer Res. 2023 Jun;43(6):2749-2755. doi: 10.21873/anticanres.16442.

Authors

Affiliations

¹ Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
² Upper Gastrointestinal and General Surgery Unit, First Department of Surgery, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece; spdavakis@gmail.com.
³ Upper Gastrointestinal and General Surgery Unit, IASO General Hospital, Athens, Greece.
⁴ First Department of Pathology, "Laikon" General Hospital, University of Athens, Medical School, Athens, Greece.
⁵ First Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Laiko General Hospital, Athens, Greece.

PMID: 37247891
DOI: 10.21873/anticanres.16442

Abstract

Background/aim: Ivor Lewis esophagectomy is considered the gold standard approach for the treatment of distal esophageal and gastro-esophageal junction Siewert I-II tumors. Minimally invasive esophagectomy has provided improved outcomes compared to the open approach, offering reduced morbidity, and improved clinical and oncological outcomes. This is the largest study so far reporting the impact of hand-sewn esophago-gastric anastomosis in the prone position, during the 2-stage totally minimally invasive esophagectomy.

Patients and methods: A retrospective analysis of prospectively collected data regarding consecutive patients with distal-esophageal and gastroesophageal junction Siewert I-II tumors was conducted. All patients underwent 2-stage totally minimally invasive esophagectomy with thoracoscopic manual esophago-gastric anastomosis in the prone position. Clinical and oncological outcomes were examined and presented.

Results: One hundred and fifty consecutive patients were included in the study during a period of five years. Median operative time was 320 minutes, while median time for the construction of anastomosis was 45 minutes. We had no conversions to open esophagectomy. Anastomotic leakage was observed in 2% of the patients; anastomotic stricture rate reached up to 7.33%. Respiratory complications were seen in 18% and cardiac complications in 6.66% of the patients, respectively. Thirty-day mortality and 90-day mortality rates were 1.33% and 2.66%, accordingly.

Conclusion: Intrathoracic hand-sewn esophago-gastric anastomosis in the prone position during totally minimally invasive esophagectomy has provided favorable outcomes in our cohort of patients, offering significantly reduced anastomotic-related complications, compared to other standardized techniques. Further prospective comparative studies are needed, to better interpret and amplify our results, that may lead to a paradigm shift regarding the preferred method of reconstruction from esophageal surgeons.

Keywords: Esophageal cancer; anastomotic leak; hand-sewn esophago-gastric anastomosis; outcomes; totally minimally invasive esophagectomy.

MeSH terms

Anastomosis, Surgical / adverse effects
Anastomotic Leak / etiology
Esophageal Neoplasms* / complications
Esophagectomy* / adverse effects
Esophagectomy* / methods
Humans
Postoperative Complications / etiology
Retrospective Studies
Treatment Outcome