Emerging role of RNA acetylation modification ac4C in diseases: Current advances and future challenges

Jie Luo; Jingsong Cao; Cong Chen; Haitao Xie

doi:10.1016/j.bcp.2023.115628

Emerging role of RNA acetylation modification ac4C in diseases: Current advances and future challenges

Biochem Pharmacol. 2023 Jul:213:115628. doi: 10.1016/j.bcp.2023.115628. Epub 2023 May 27.

Authors

Jie Luo¹, Jingsong Cao², Cong Chen¹, Haitao Xie³

Affiliations

¹ Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
² Department of Endocrinology and Metabolism, The First Affiliated Hospital, Institute of Clinical Medicine, University of South China, Hengyang 421001, China.
³ Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address: xiehaitao1213@163.com.

PMID: 37247745
DOI: 10.1016/j.bcp.2023.115628

Abstract

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely distributed from archaea to eukaryotes and acts as a posttranscriptional chemical modification of RNA, contributing to the correct reading of specific nucleotide sequences during translation, stabilising mRNA and improving transcription efficiency. Yeast Kre33 and human NAT10, the only known authors of ac4C, modify tRNA with the help of the Tan1/THUMPD1 adapter to stabilise its structure. Currently, the mRNA for N4-acetylcytidine (ac4C), catalysed by NAT10 (N-acetyltransferase 10), has been implicated in a variety of human diseases, particularly cancer. This article reviews advances in the study of ac4C modification of RNA and the ac4C-related gene NAT10 in normal physiological cell development, cancer, premature disease and viral infection and discusses its therapeutic promise and future research challenges.

Keywords: Cancer; EMT; HGPS; N4-acetylcytidine; NAT10; ac4C.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Cytidine* / genetics
Cytidine* / metabolism
Humans
RNA*
RNA, Messenger / genetics
RNA-Binding Proteins
Saccharomyces cerevisiae / genetics

Substances

N-acetylcytidine
RNA
Cytidine
RNA, Messenger
THUMPD1 protein, human
RNA-Binding Proteins