Digital Biomarkers and the Evolution of Spine Care Outcomes Measures: Smartphones and Wearables

Neurosurgery. 2023 Oct 1;93(4):745-754. doi: 10.1227/neu.0000000000002519. Epub 2023 May 29.

Abstract

Over the past generation, outcome measures in spine care have evolved from a reliance on clinician-reported assessment toward recognizing the importance of the patient's perspective and the wide incorporation of patient-reported outcomes (PROs). While patient-reported outcomes are now considered an integral component of outcomes assessments, they cannot wholly capture the state of a patient's functionality. There is a clear need for quantitative and objective patient-centered outcome measures. The pervasiveness of smartphones and wearable devices in modern society, which passively collect data related to health, has ushered in a new era of spine care outcome measurement. The patterns emerging from these data, so-called "digital biomarkers," can accurately describe characteristics of a patient's health, disease, or recovery state. Broadly, the spine care community has thus far concentrated on digital biomarkers related to mobility, although the researcher's toolkit is anticipated to expand in concert with advancements in technology. In this review of the nascent literature, we describe the evolution of spine care outcome measurements, outline how digital biomarkers can supplement current clinician-driven and patient-driven measures, appraise the present and future of the field in the modern era, as well as discuss present limitations and areas for further study, with a focus on smartphones (see Supplemental Digital Content , http://links.lww.com/NEU/D809 , for a similar appraisal of wearable devices).

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Humans
  • Outcome Assessment, Health Care
  • Smartphone*
  • Spine
  • Wearable Electronic Devices*

Substances

  • Biomarkers