Re-irradiation in Paediatric Tumours of the Central Nervous System: National Guidelines from the Swedish Workgroup of Paediatric Radiotherapy

A Embring; M Blomstrand; A Asklid; M P Nilsson; M Agrup; A-M Svärd; C Fröjd; U Martinsson; I Fagerström Kristensen; J Engellau

doi:10.1016/j.clon.2023.05.007

Re-irradiation in Paediatric Tumours of the Central Nervous System: National Guidelines from the Swedish Workgroup of Paediatric Radiotherapy

Clin Oncol (R Coll Radiol). 2023 Sep;35(9):571-575. doi: 10.1016/j.clon.2023.05.007. Epub 2023 May 19.

Authors

A Embring¹, M Blomstrand², A Asklid³, M P Nilsson⁴, M Agrup⁵, A-M Svärd⁶, C Fröjd⁷, U Martinsson⁸, I Fagerström Kristensen⁹, J Engellau⁴

Affiliations

¹ Department of Oncology, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden. Electronic address: anna.embring@ki.se.
² Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Oncology, Institute of Clinical Sciences, University of Gothenburg, Sweden.
³ Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
⁴ Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
⁵ Department of Oncology, Linköping University, Linköping, Sweden; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
⁶ Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
⁷ Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁸ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
⁹ Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden; Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden.

PMID: 37246041
DOI: 10.1016/j.clon.2023.05.007

Abstract

There is a lack of clinical protocols for re-irradiation in paediatric central nervous system (CNS) tumours. To fill this void, the Swedish Workgroup of Paediatric Radiotherapy (SBRTG) compiled national guidelines on re-irradiation in paediatric CNS tumours (diffuse intrinsic pontine glioma, ependymoma, germinoma and medulloblastoma). These have been in clinical practice since 2019 in all paediatric radiotherapy centres in Sweden. Since the implementation, the guidelines have been complemented with a yearly review on clinical outcome and toxicities in all paediatric patients treated according to the guidelines. This article presents the Swedish national guidelines on re-irradiation in paediatric CNS tumours.

Keywords: CNS tumours; Clinical protocol; national guidelines; paediatric; re-irradiation; tumours of the central nervous system.

MeSH terms

Central Nervous System
Cerebellar Neoplasms*
Child
Humans
Medulloblastoma* / radiotherapy
Re-Irradiation*
Sweden