Renal Cell Carcinoma of Variant Histology: Biology and Therapies

Pavlos Msaouel; Giannicola Genovese; Nizar M Tannir

doi:10.1016/j.hoc.2023.04.019

Renal Cell Carcinoma of Variant Histology: Biology and Therapies

Hematol Oncol Clin North Am. 2023 Oct;37(5):977-992. doi: 10.1016/j.hoc.2023.04.019. Epub 2023 May 25.

Authors

Pavlos Msaouel¹, Giannicola Genovese², Nizar M Tannir³

Affiliations

¹ Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: pmsaouel@mdanderson.org.
² Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA; TRACTION Platform, Division of Therapeutic Discoveries, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
³ Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 37244822
DOI: 10.1016/j.hoc.2023.04.019

Abstract

The term variant histology renal cell carcinomas (vhRCCs), also known as non-clear cell RCCs, refers to a diverse group of malignancies with distinct biologic and therapeutic considerations. The management of vhRCC subtypes is often based on extrapolating results from the more common clear cell RCC studies or basket trials that are not specific to each histology. The unique management of each vhRCC subtype necessitates accurate pathologic diagnosis and dedicated research efforts. Herein, we discuss tailored recommendations for each vhRCC histology informed by ongoing research and clinical experience.

Keywords: Chromophobe renal cell carcinoma; Collecting duct carcinoma; MiTF translocation renal cell carcinoma; Nonclear cell renal cell carcinoma; Papillary renal cell carcinoma; Renal medullary carcinoma.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biology
Carcinoma, Renal Cell* / diagnosis
Carcinoma, Renal Cell* / pathology
Carcinoma, Renal Cell* / therapy
Humans
Kidney Neoplasms* / diagnosis
Kidney Neoplasms* / pathology
Kidney Neoplasms* / therapy

Abstract

Publication types

MeSH terms

Grants and funding