Triterpenoids from the fruits of Melia toosendan Sieb. et Zucc. with α-glucosidase inhibitory activities

Rui Guo; Ya-Tian Meng; Xiao-Juan Cao; Cun-Lin Wang; Xin Qiao; Qiong Zhang

doi:10.1016/j.fitote.2023.105550

Triterpenoids from the fruits of Melia toosendan Sieb. et Zucc. with α-glucosidase inhibitory activities

Fitoterapia. 2023 Jul:168:105550. doi: 10.1016/j.fitote.2023.105550. Epub 2023 May 25.

Authors

Rui Guo¹, Ya-Tian Meng¹, Xiao-Juan Cao¹, Cun-Lin Wang¹, Xin Qiao¹, Qiong Zhang²

Affiliations

¹ School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030000, PR China.
² School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030000, PR China. Electronic address: zhangqiong@sxmu.edu.cn.

PMID: 37244502
DOI: 10.1016/j.fitote.2023.105550

Abstract

Four previously unreported tirucallane-type triterpenoids (1-4), together with four known analogues (5-8), were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their planar structures were comprehensively elucidated by detailed analyses of HRESIMS, 1D and 2D NMR spectra data. The relative configurations of 1-4 were determined by NOESY experiments. The comparison of experimental and calculated electronic circular dichroism (ECD) spectra led to the establishment of the absolute configurations of new compounds. All isolated triterpenoids were evaluated for their α-glucosidase inhibitory activities in vitro. Compounds 4 and 5 showed moderate α-glucosidase inhibitory activities with IC₅₀ values of 120.3 ± 5.8 and 104.9 ± 7.1 μM, respectively.

Keywords: Melia toosendan Sieb. et Zucc.; Meliaceae; Triterpenoids; α-Glucosidase inhibitory activities.

MeSH terms

Fruit / chemistry
Melia* / chemistry
Molecular Structure
Triterpenes* / chemistry
Triterpenes* / pharmacology
alpha-Glucosidases

Substances

alpha-Glucosidases
Triterpenes