Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy

Adriano B Chaves-Filho; Almut Schulze

doi:10.1016/j.ccell.2023.05.013

Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy

Cancer Cell. 2023 Jul 10;41(7):1204-1206. doi: 10.1016/j.ccell.2023.05.013. Epub 2023 May 26.

Authors

Adriano B Chaves-Filho¹, Almut Schulze²

Affiliations

¹ Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany; Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 1524, São Paulo 05508000, Brazil.
² Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: almut.schulze@dkfz-heidelberg.de.

PMID: 37244258
DOI: 10.1016/j.ccell.2023.05.013

Abstract

Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Immunotherapy, Adoptive
Neoplasms* / therapy
Receptors, Chimeric Antigen*
T-Lymphocytes, Cytotoxic
Tumor Microenvironment

Substances

Receptors, Chimeric Antigen