A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials

Zi-Jie Zhang; Lu-Yue Ding; Xiao-Lei Zuo; Hao Feng; Qiang Xia

doi:10.1016/j.medj.2023.05.002

A new paradigm in transplant immunology: At the crossroad of synthetic biology and biomaterials

Med. 2023 Jul 14;4(7):404-431. doi: 10.1016/j.medj.2023.05.002. Epub 2023 May 26.

Authors

Zi-Jie Zhang¹, Lu-Yue Ding², Xiao-Lei Zuo³, Hao Feng⁴, Qiang Xia⁵

Affiliations

¹ Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai 200127, China.
² Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
³ Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai 200127, China; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
⁴ Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai 200127, China; Shanghai Institute of Transplantation, Shanghai 200127, China; Punan Branch (Shanghai Punan Hospital), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: surgeonfeng@live.com.
⁵ Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Shanghai Engineering Research Centre of Transplantation and Immunology, Shanghai 200127, China; Shanghai Institute of Transplantation, Shanghai 200127, China. Electronic address: xiaqiang@medmail.com.cn.

PMID: 37244257
DOI: 10.1016/j.medj.2023.05.002

Abstract

Solid organ transplant (SOT) recipients require meticulously tailored immunosuppressive regimens to minimize graft loss and mortality. Traditional approaches focus on inhibiting effector T cells, while the intricate and dynamic immune responses mediated by other components remain unsolved. Emerging advances in synthetic biology and material science have provided novel treatment modalities with increased diversity and precision to the transplantation community. This review investigates the active interface between these two fields, highlights how living and non-living structures can be engineered and integrated for immunomodulation, and discusses their potential application in addressing the challenges in SOT clinical practice.

Publication types

Review

MeSH terms

Biocompatible Materials / therapeutic use
Immunosuppressive Agents / therapeutic use
Organ Transplantation*
Synthetic Biology
Transplants*

Substances

Biocompatible Materials
Immunosuppressive Agents