Chronic Epstein-Barr virus infection: A potential junction between primary Sjögren's syndrome and lymphoma

Lufei Yang; Jincheng Pu; Feiyang Cai; Youwei Zhang; Ronglin Gao; Shuqi Zhuang; Yuanyuan Liang; Zhenzhen Wu; Shengnan Pan; Jiamin Song; Fang Han; Jianping Tang; Xuan Wang

doi:10.1016/j.cyto.2023.156227

Chronic Epstein-Barr virus infection: A potential junction between primary Sjögren's syndrome and lymphoma

Cytokine. 2023 Aug:168:156227. doi: 10.1016/j.cyto.2023.156227. Epub 2023 May 25.

Authors

Affiliations

¹ Department of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
² Department of Experimental Medicine, Faculty of Medicine, McGill University, Montréal, Québec, Canada; Gerald Bronfman Department of Oncology, Segal Cancer Centre, Lady Davis Institute and Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
³ Department of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: tangjp6512@126.com.
⁴ Department of Rheumatology and Immunology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: xuan2018@tongji.edu.cn.

PMID: 37244248
DOI: 10.1016/j.cyto.2023.156227

Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune disease that targets exocrine glands, leading to exocrine dysfunction. Due to its propensity to infect epithelial and B cells, Epstein-Barr virus (EBV) is hypothesized to be related with pSS. Through molecular mimicry, the synthesis of specific antigens, and the release of inflammatory cytokines, EBV contributes to the development of pSS. Lymphoma is the most lethal outcome of EBV infection and the development of pSS. As a population-wide virus, EBV has had a significant role in the development of lymphoma in people with pSS. In the review, we will discuss the possible causes of the disease.

Keywords: Epstein-Barr virus; Lymphoma; Pathogenesis; Primary Sjögren’s syndrome.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases* / complications
Epstein-Barr Virus Infections* / complications
Herpesvirus 4, Human
Humans
Lymphoma*
Sjogren's Syndrome*