Paper-based bipolar electrode electrochemiluminescence sensors for point-of-care testing

Tinglei Ma; Suyue Ren; Yixiang Wang; Haihan Yu; Lin Li; Xu Li; Luqing Zhang; Jinghua Yu; Yan Zhang

doi:10.1016/j.bios.2023.115384

Paper-based bipolar electrode electrochemiluminescence sensors for point-of-care testing

Biosens Bioelectron. 2023 Sep 1:235:115384. doi: 10.1016/j.bios.2023.115384. Epub 2023 May 18.

Authors

Tinglei Ma¹, Suyue Ren¹, Yixiang Wang¹, Haihan Yu¹, Lin Li¹, Xu Li¹, Luqing Zhang², Jinghua Yu³, Yan Zhang⁴

Affiliations

¹ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China.
² School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China. Electronic address: chm_zhanglq@ujn.edu.cn.
³ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China. Electronic address: ujn.yujh@gmail.com.
⁴ School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Qingdao University of Science and Technology, Qingdao, 266042, China. Electronic address: chm_zhangyan@hotmail.com.

PMID: 37244092
DOI: 10.1016/j.bios.2023.115384

Abstract

In the past few years, point-of-care testing (POCT) technology has crossed the boundaries of laboratory determination and entered the stage of practical applications. Herein, the latest advances and principal issues in the design and fabrication of paper-based bipolar electrode electrochemiluminescence (BPE-ECL) sensors, which are widely used in the POCT field, are highlighted. After introducing the attractive physical and chemical properties of cellulose paper, various approaches aimed at enhancing the functions of the paper, and their underlying principles are described. The materials typically employed for fabricating paper-based BPE are also discussed in detail. Subsequently, the universal method of enhancing BPE-ECL signal and improving detection accuracy is put forward, and the ECL detector widely used is introduced. Furthermore, the application of paper-based BPE-ECL sensors in biomedical, food, environmental and other fields are displayed. Finally, future opportunities and the remaining challenges are analyzed. It is expected that more design concepts and working principles for paper-based BPE-ECL sensors will be developed in the near future, paving the way for the development and application of paper-based BPE-ECL sensors in the POCT field and providing certain guarantee for the development of human health.

Keywords: Bipolar electrode; Electrochemiluminescence; Paper; Point-of-care testing.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Electrochemical Techniques / methods
Electrodes
Humans
Luminescent Measurements* / methods
Point-of-Care Testing