2-Oxo-imidazole dipeptides inhibit peroxynitrite-dependent tyrosine nitration

Abstract

Carnosine and anserine were reported to inhibit tyrosine nitration. However, there are no reports on the nitration inhibitory activities of balenine, 2-oxo-carnosine, 2-oxo-anserine, and 2-oxo-balenine. We demonstrated for the first time that these compounds exhibit inhibitory activities against peroxynitrite-dependent tyrosine nitration. 2-Oxo-imidazole dipeptides (2-oxo-IDPs) showed higher inhibitory activity than their precursor IDPs, thereby suggesting that 2-oxo-IDPs may be effective against nitrative stress-related diseases.

Keywords: 2-Oxo-imidazole dipeptides; Anserine; Balenine; Carnosine; Imidazole dipeptides; Tyrosine nitration.