The process of cellular transformation encompasses the acquisition of key and distinctive features, commonly known as hallmarks of cancer. These hallmarks are supported by tumor-intrinsic molecular alterations, as well as changes in the microenvironment. Cellular metabolism represents one of the most intimate connections between a cell and the environment. In turn, metabolic adaptation is a research field of increasing interest in cancer biology. In this viewpoint, I will provide a panoramic perspective of the relevance and repercussions of metabolic alterations in tumors with nonexhaustive illustrative examples and I will speculate about the prospects of cancer metabolism research.
Keywords: anabolism; cancer metabolism; metabolic vulnerability; tumor microenvironment.
© 2023 The Author. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.