Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Anna A Antsiferova; Marina Yu Kopaeva; Vyacheslav N Kochkin; Alexander A Reshetnikov; Pavel K Kashkarov

doi:10.3390/mi14050984

Neurotoxicity of Silver Nanoparticles and Non-Linear Development of Adaptive Homeostasis with Age

Micromachines (Basel). 2023 Apr 30;14(5):984. doi: 10.3390/mi14050984.

Authors

Anna A Antsiferova^{1

2}, Marina Yu Kopaeva¹, Vyacheslav N Kochkin¹, Alexander A Reshetnikov¹, Pavel K Kashkarov^{1

2

3}

Affiliations

¹ National Research Center "Kurchatov Institute", Akademika Kurchatova sq., 123182 Moscow, Russia.
² Moscow Institute of Physics and Technologies, Institutskii Lane, Moscow Region, 141700 Dolgoprudny, Russia.
³ Department of Physics, Lomonosov Moscow State University, GSP-1, Leninskiye Gory, 119991 Moscow, Russia.

Abstract

For the first time in the world, the behavioral functions of laboratory mammals exposed to silver nanoparticles were studied with regard to age. Silver nanoparticles coated with polyvinylpyrrolidone with a size of 8.7 nm were used in the present research as a potential xenobiotic. Elder mice adapted to the xenobiotic better than the younger animals. Younger animals demonstrated more drastic anxiety than the elder ones. A hormetic effect of the xenobiotic in elder animals was observed. Thus, it is concluded that adaptive homeostasis non-linearly changes with age increase. Presumably, it may improve during the prime of life and start to decline just after a certain stage. This work demonstrates that age growth is not directly conjugated with the organism fading and pathology development. Oppositely, vitality and resistance to xenobiotics may even improve with age at least until the prime of life.

Keywords: adaptive homeostasis; ageing; anxiety; behavioral functions; bioaccumulation; individual content; mice; nanoparticle; neutron activation analysis; silver nanoparticles.

Grants and funding

The study was partially supported by the Ministry of Science and Higher Education of the Russian Federation, the contract 075-15-2021-709, unique identifier of the project RF-2296.61321X0037 (equipment maintenance).