The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury

Ping Zhou; Shun Zhang; Maohua Wang; Jun Zhou

doi:10.3390/biom13050820

The Induction Mechanism of Ferroptosis, Necroptosis, and Pyroptosis in Inflammatory Bowel Disease, Colorectal Cancer, and Intestinal Injury

Biomolecules. 2023 May 11;13(5):820. doi: 10.3390/biom13050820.

Authors

Ping Zhou^{1

2}, Shun Zhang^{1

2}, Maohua Wang^{1

2}, Jun Zhou^{1

2}

Affiliations

¹ Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
² Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Luzhou 646000, China.

Abstract

Cell death includes programmed and nonprogrammed cell death. The former mainly includes ferroptosis, necroptosis, pyroptosis, autophagy, and apoptosis, while the latter refers to necrosis. Accumulating evidence shows that ferroptosis, necroptosis, and pyroptosis play essential regulatory roles in the development of intestinal diseases. In recent years, the incidence of inflammatory bowel disease (IBD), colorectal cancer (CRC), and intestinal injury induced by intestinal ischemia-reperfusion (I/R), sepsis, and radiation have gradually increased, posing a significant threat to human health. The advancement in targeted therapies for intestinal diseases based on ferroptosis, necroptosis, and pyroptosis provides new strategies for treating intestinal diseases. Herein, we review ferroptosis, necroptosis, and pyroptosis with respect to intestinal disease regulation and highlight the underlying molecular mechanisms for potential therapeutic applications.

Keywords: colorectal cancer; ferroptosis; inflammatory bowel disease; intestinal injury; necroptosis; pyroptosis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Colorectal Neoplasms* / genetics
Ferroptosis*
Humans
Inflammatory Bowel Diseases* / genetics
Necroptosis
Pyroptosis

Grants and funding

This research was funded by the National Natural Science Foundation of China, grant number 81873930, and the Sichuan Science and Technology Program, grant number 2022YFS0632 and 2020YJ0189.