Mechanisms Controlling the Expression and Secretion of BDNF

Juan Carlos Arévalo; Rubén Deogracias

doi:10.3390/biom13050789

Mechanisms Controlling the Expression and Secretion of BDNF

Biomolecules. 2023 May 2;13(5):789. doi: 10.3390/biom13050789.

Authors

Juan Carlos Arévalo^{1

2}, Rubén Deogracias^{1

2}

Affiliations

¹ Department of Cell Biology and Pathology, Institute of Neurosciences of Castille and Leon (INCyL), University of Salamanca, 37007 Salamanca, Spain.
² Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.

Abstract

Brain-derived nerve factor (BDNF), through TrkB receptor activation, is an important modulator for many different physiological and pathological functions in the nervous system. Among them, BDNF plays a crucial role in the development and correct maintenance of brain circuits and synaptic plasticity as well as in neurodegenerative diseases. The proper functioning of the central nervous system depends on the available BDNF concentrations, which are tightly regulated at transcriptional and translational levels but also by its regulated secretion. In this review we summarize the new advances regarding the molecular players involved in BDNF release. In addition, we will address how changes of their levels or function in these proteins have a great impact in those functions modulated by BDNF under physiological and pathological conditions.

Keywords: BDNF; Ca2+; expression; nerve cells; neurotrophin release; neurotrophins; proBDNF; secretion; synaptic activity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain* / metabolism
Brain-Derived Neurotrophic Factor* / genetics
Brain-Derived Neurotrophic Factor* / metabolism
Central Nervous System / metabolism
Neuronal Plasticity / physiology
Receptor, trkB / genetics
Receptor, trkB / metabolism

Substances

Brain-Derived Neurotrophic Factor
Receptor, trkB

Grants and funding

Research in Juan Carlos Arévalo’s and Rubén Deogracias’ laboratories was funded by MCIN/AEI/10.13039/501100011033, grant numbers PID2020-113130RB-100 to JCA, RYC2018-025215-I and PID2020-113086RB-100 to RD.