A Case Report of Early-Onset Alzheimer's Disease Using 18F-FDG PET and 18F-FBB PET

Jang Yoo; Miju Cheon; Min-Ju Kang

doi:10.3390/diagnostics13101671

A Case Report of Early-Onset Alzheimer's Disease Using ¹⁸F-FDG PET and ¹⁸F-FBB PET

Diagnostics (Basel). 2023 May 9;13(10):1671. doi: 10.3390/diagnostics13101671.

Authors

Jang Yoo¹, Miju Cheon¹, Min-Ju Kang²

Affiliations

¹ Department of Nuclear Medicine, VHS Medical Center, Seoul 05368, Republic of Korea.
² Department of Neurology, VHS Medical Center, Seoul 05368, Republic of Korea.

Abstract

We describe a 40-year-old female patient who presented with sleep disturbance, intermittent headache, and gradual subjective cognitive decline. ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) showed mild FDG hypometabolism in bilateral parietal and temporal lobes. However, ¹⁸F-florbetaben (FBB) amyloid PET revealed diffuse amyloid retention in the lateral temporal cortex, frontal cortex, posterior cingulate cortex/precuneus, parietal cortex, and cerebellum. This finding supports the clinical significance of amyloid imaging in diagnostic work-up of early-onset Alzheimer's disease (EOAD).

Keywords: 18F-FDG PET; 18F-florbetaben PET; case report; early-onset Alzheimer’s disease.

Grants and funding

VHSMC 20062/VHS Medical Center Research Grant