Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

TianRong Ma; XiaoLei Xue; Hui Tian; XinXiu Zhou; JunKe Wang; ZhiWen Zhao; MingFei Wang; JiYuan Song; RenXiang Feng; Leping Li; Changqing Jing; Feng Tian

doi:10.1186/s12967-023-04215-2

Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

J Transl Med. 2023 May 26;21(1):349. doi: 10.1186/s12967-023-04215-2.

Authors

TianRong Ma^#¹, XiaoLei Xue^#^{1

2}, Hui Tian^#³, XinXiu Zhou¹, JunKe Wang¹, ZhiWen Zhao¹, MingFei Wang⁴, JiYuan Song⁴, RenXiang Feng⁴, Leping Li^{1

4}, Changqing Jing^{5

6}, Feng Tian^{7

8}

Affiliations

¹ Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
² Department of Pharmacy, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China.
³ Department of Gastroenterology, Liaocheng People's Hospital, Shandong First Medical University, Liaocheng, 252000, China.
⁴ Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China.
⁵ Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. jingchangqing@sdfmu.edu.cn.
⁶ Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China. jingchangqing@sdfmu.edu.cn.
⁷ Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. tianfeng_nju@163.com.
⁸ Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China. tianfeng_nju@163.com.

^# Contributed equally.

Abstract

Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.

Keywords: Gut microbiota; Intestinal motility; Metabolites; Postoperative ileus; Probiotics; Review.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Dysbiosis
Gastrointestinal Microbiome*
Gastrointestinal Motility
Humans
Intestines / physiology