Solid pseudopapillary tumor of the pancreas: A systematic review of clinical, surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

Gennaro Mazzarella; Edoardo Maria Muttillo; Diego Coletta; Biagio Picardi; Stefano Rossi; Simone Rossi Del Monte; Vito Gomes; Irnerio Angelo Muttillo

doi:10.1016/j.hbpd.2023.05.004

Solid pseudopapillary tumor of the pancreas: A systematic review of clinical, surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

Hepatobiliary Pancreat Dis Int. 2023 May 14:S1499-3872(23)00074-7. doi: 10.1016/j.hbpd.2023.05.004. Online ahead of print.

Authors

Gennaro Mazzarella¹, Edoardo Maria Muttillo², Diego Coletta³, Biagio Picardi⁴, Stefano Rossi⁴, Simone Rossi Del Monte⁴, Vito Gomes⁵, Irnerio Angelo Muttillo⁴

Affiliations

¹ Division of General and Emergency Surgery, San Filippo Neri Hospital, 00136 Rome, Italy; Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy. Electronic address: gennaromazzarella226@gmail.com.
² Division of General and Emergency Surgery, San Filippo Neri Hospital, 00136 Rome, Italy; Surgical and Medical Department of Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00185 Rome, Italy.
³ Department of Surgical Sciences, Umberto I University Hospital, Sapienza University of Rome, 00136 Rome, Italy; Department of General Surgery, Ospedali Riuniti Marche Nord, 61121 Pesaro, Italy.
⁴ Division of General and Emergency Surgery, San Filippo Neri Hospital, 00136 Rome, Italy.
⁵ Department of Pathology, San Filippo Neri Hospital, 00136 Rome, Italy.

PMID: 37236826
DOI: 10.1016/j.hbpd.2023.05.004

Abstract

Background: Pancreatic solid pseudopapillary tumors (SPTs) are rare clinical entity, with low malignancy and still unclear pathogenesis. They account for less than 2% of exocrine pancreatic neoplasms. This study aimed to perform a systematic review of the main clinical, surgical and oncological characteristics of pancreatic SPTs.

Data sources: MEDLINE/PubMed, Web of Science and Scopus databases were systematically searched for the main clinical, surgical and oncological characteristics of pancreatic SPTs up to April 2021, in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) standards. Primary endpoints were to analyze treatments and oncological outcomes.

Results: A total of 823 studies were recorded, 86 studies underwent full-text reviews and 28 met inclusion criteria. Overall, 1384 patients underwent pancreatic surgery. Mean age was 30 years and 1181 patients (85.3%) were female. The most common clinical presentation was non-specific abdominal pain (52.6% of cases). Mean overall survival was 98.1%. Mean recurrence rate was 2.8%. Mean follow-up was 4.2 years.

Conclusions: Pancreatic SPTs are rare, and predominantly affect young women with unclear pathogenesis. Radical resection is the gold standard of treatment achieving good oncological impact and a favorable prognosis in a yearly life-long follow-up.

Keywords: Frantz's tumor; Pancreas; Pancreatic neoplasms; Pancreatic surgery; Solid pseudopapillary tumor.

Publication types

Review