The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

Xiao Wang; Ruiqi Liu; Shuang Li; Wenjie Xia; Haiwei Guo; Weiping Yao; Xiaodong Liang; Yanwei Lu; Haibo Zhang

doi:10.1016/j.biopha.2023.114929

The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

Biomed Pharmacother. 2023 Aug:164:114929. doi: 10.1016/j.biopha.2023.114929. Epub 2023 May 24.

Authors

Xiao Wang¹, Ruiqi Liu², Shuang Li³, Wenjie Xia⁴, Haiwei Guo⁵, Weiping Yao², Xiaodong Liang³, Yanwei Lu⁶, Haibo Zhang⁷

Affiliations

¹ Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
² Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Graduate Department, Bengbu Medical College, Bengbu, Anhui, China.
³ Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
⁴ General Surgery, Cancer Center, Department of Breast Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
⁵ Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People' s Hospital, Affiliated People's Hospital, Hangzhou Medical College, 310014, Hangzhou, Zhejiang, China.
⁶ Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address: luyanwei@hmc.edu.cn.
⁷ Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address: zhbdoctor@163.com.

PMID: 37236028
DOI: 10.1016/j.biopha.2023.114929

Abstract

Cyclin-dependent kinase 16 (CDK16) is an orphan "cyclin-dependent kinase" (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers.

Keywords: CDK16; Cancer; Cell cycle; PCTAIRE1; PCTK1.

Publication types

Review

MeSH terms

Animals
Cell Cycle
Cell Division
Cyclins / metabolism
Humans
Lung Neoplasms*
Male
Skin Neoplasms*

Substances

Cyclins
PCTAIRE-1 protein kinase