Role of exosomal noncoding RNA in esophageal carcinoma

Mao-Yan Si; Ding-Yu Rao; Yao Xia; Cheng-Peng Sang; Kai-Yun Mao; Xiang-Jin Liu; Zu-Xiong Zhang; Zhi-Xian Tang

doi:10.3389/fonc.2023.1126890

Role of exosomal noncoding RNA in esophageal carcinoma

Front Oncol. 2023 May 9:13:1126890. doi: 10.3389/fonc.2023.1126890. eCollection 2023.

Authors

Mao-Yan Si¹, Ding-Yu Rao², Yao Xia¹, Cheng-Peng Sang³, Kai-Yun Mao¹, Xiang-Jin Liu¹, Zu-Xiong Zhang², Zhi-Xian Tang²

Affiliations

¹ First Clinical Medical College, Gannan Medical University, Ganzhou, China.
² Department of Cardiothoracic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
³ Department of Cardiothoracic Surgery, The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an, Jiangsu, China.

Abstract

Esophageal cancer is a common malignant tumor with a high degree of malignancy. Understanding its pathogenesis and identifying early diagnostic biomarkers can significantly improve the prognosis of esophageal cancer patients. Exosomes are small double-membrane vesicles found in various body fluids containing various components (DNA, RNA, and proteins) that mediate intercellular signal communication. Non-coding RNAs are a class of gene transcription products that encode polypeptide functions and are widely detected in exosomes. There is growing evidence that exosomal non-coding RNAs are involved in cancer growth, metastasis and angiogenesis, and can also be used as diagnostic and prognostic markers. This article reviews the recent progress in exosomal non-coding RNAs in esophageal cancer, including research progress, diagnostic value, proliferation, migration, invasion, and drug resistance, provide new ideas for the precise treatment of esophageal cancer.

Keywords: IncRNA; esophageal cancer; exosomes; miRNA; prospects.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Funds of China (Nos. 81860337, 81960326, 82060384); Natural Science Funds of Jiangxi Province (Nos. 20202ACBL206014, 20192BAB205009, 2020BABL206116); Science and Technology Program of Jiangxi Health Commission (Nos. 20201080, 202130660); National Health Commission Science and Technology Development Research Center (No. 2019ZH-07E-003); general projects of Jiangxi Traditional Chinese Medicine Science and Technology (No. 2020B0214).