Traditional Chinese medicine for heart failure with preserved ejection fraction: clinical evidence and potential mechanisms

Front Pharmacol. 2023 May 10:14:1154167. doi: 10.3389/fphar.2023.1154167. eCollection 2023.

Abstract

Heart failure with preserved ejection fraction accounts for a large proportion of heart failure, and it is closely related to a high hospitalization rate and high mortality rate of cardiovascular disease. Although the methods and means of modern medical treatment of HFpEF are becoming increasingly abundant, they still cannot fully meet the clinical needs of HFpEF patients. Traditional Chinese medicine is an important complementary strategy for the treatment of diseases in modern medicine, and it has been widely used in clinical research on HFpEF in recent years. This article reviews the current situation of HFpEF management, the evolution of guidelines, the clinical evidence and the mechanism of TCM in the treatment of HFpEF. The purpose of this study is to explore the application of TCM for HFpEF, to further improve the clinical symptoms and prognosis of patients and to provide a reference for the diagnosis and treatment of the disease.

Keywords: cardiovascular disease; clinical evidence; heart failure with preserved ejection fraction; potential mechanisms; traditional Chinese medicine.

Publication types

  • Review

Grants and funding

This work was supported by the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine (No: ZYYCXTD-C-202203), the “Innovation Team Development Plan” of the Ministry of Education-Research on the prevention and treatment of cardiovascular diseases in traditional Chinese medicine (No: IRT_16R54). We also thank Biorender (https://biorender.com/) for design of the online figures by Biorender and its linguistic assistance during the preparation of this manuscript.