New Glycerolipids from the Traditional Chinese Medicine of Syngnathus acus (Hai-Long)

Abstract

Two new glycerolipids, syngaculipids A and B (1 and 2), one first naturally occurring metabolite (8), together with five known compounds (3-7) were isolated from the AcOEt fraction of Syngnathus acus L. (Hai-Long). Their structures were elucidated by comprehensive spectral analyses involving UV, IR, MS, 1D and 2D NMR spectra and ECD calculations. All the isolated compounds were evaluated for their cytotoxicity against A549 and HCT-116 cell lines. Compound 8 exhibited moderate cytotoxicity with IC₅₀ values of 34.5 and 38.9 μM on the A549 and HCT-116 cell lines, respectively.

Keywords: ECD calculation; Syngnathus acus; cytotoxicity; glycerolipids; traditional Chinese medicine.