Mesenchymal stem cells and allergic airway inflammation; a therapeutic approach to induce immunoregulatory responses

Mohammad Gholami; Khodayar Ghorban; Mahvash Sadeghi; Maryam Dadmanesh; Negin Hosseini Rouzbahani; Sajad Dehnavi

doi:10.1016/j.intimp.2023.110367

Mesenchymal stem cells and allergic airway inflammation; a therapeutic approach to induce immunoregulatory responses

Int Immunopharmacol. 2023 Jul:120:110367. doi: 10.1016/j.intimp.2023.110367. Epub 2023 May 23.

Authors

Mohammad Gholami¹, Khodayar Ghorban², Mahvash Sadeghi³, Maryam Dadmanesh⁴, Negin Hosseini Rouzbahani⁵, Sajad Dehnavi⁶

Affiliations

¹ Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran; Department of Medical Microbiology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran.
² Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran.
³ Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁴ Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran; Department of Infectious Diseases, School Of Medicine, Aja University of Medical Sciences, Tehran, Iran.
⁵ Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran; Department of Immunology, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran.
⁶ Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: sjd72dehnavi@gmail.com.

PMID: 37230032
DOI: 10.1016/j.intimp.2023.110367

Abstract

Allergic airway inflammations are among the essential disorders worldwide that are already considered a significant concern. Mesenchymal stem cells (MSCs) are stromal cells with regenerative potential and immunomodulatory characteristics and are widely administered for tissue repair as an immunoregulatory agent in different inflammatory diseases. The current review summarized primary studies conducted to evaluate the therapeutic potential of MSCs for allergic airway disorders. In this case, modulation of airway pathologic inflammation and infiltration of inflammatory cells were examined, and modulation of the Th1/Th2 cellular balance and humoral responses. Also, the effects of MSCs on the Th17/Treg ratio and inducing Treg immunoregulatory responses along with macrophage and dendritic cell function were evaluated.

Keywords: Airway allergic inflammation; Allergic asthma; Allergic rhinitis; Immunomodulation; mesenchymal stem cell (MSC).

Publication types

Review

MeSH terms

Humans
Immunomodulation
Inflammation / pathology
Inflammation / therapy
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells* / pathology