Abstract
Three new abietane and two new tigliane diterpenoids were isolated from the roots Euphorbia fischeriana. Their structures were elucidated by spectroscopic methods and quantum chemical calculation. Compounds 4 and 5 exhibited the inhibitory activities against human cancer cells HeLa and HepG2, with IC50 ranging from 3.54 to 11.45 µM.
Keywords:
Euphorbia fischeriana; abietane; cytotoxic activity; tigliane.
MeSH terms
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Abietanes / chemistry
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Abietanes / pharmacology
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Antineoplastic Agents*
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / pharmacology
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Diterpenes* / chemistry
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Diterpenes* / pharmacology
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Euphorbia* / chemistry
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Humans
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Molecular Structure
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Phorbols* / analysis
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Plant Roots / chemistry
Substances
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abietane
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Abietanes
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Phorbols
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Antineoplastic Agents