New abietane and tigliane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxic activities

J Asian Nat Prod Res. 2023 Jun;25(6):519-527. doi: 10.1080/10286020.2023.2197224. Epub 2023 May 25.

Abstract

Three new abietane and two new tigliane diterpenoids were isolated from the roots Euphorbia fischeriana. Their structures were elucidated by spectroscopic methods and quantum chemical calculation. Compounds 4 and 5 exhibited the inhibitory activities against human cancer cells HeLa and HepG2, with IC50 ranging from 3.54 to 11.45 µM.

Keywords: Euphorbia fischeriana; abietane; cytotoxic activity; tigliane.

MeSH terms

  • Abietanes / chemistry
  • Abietanes / pharmacology
  • Antineoplastic Agents*
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Diterpenes* / chemistry
  • Diterpenes* / pharmacology
  • Euphorbia* / chemistry
  • Humans
  • Molecular Structure
  • Phorbols* / analysis
  • Plant Roots / chemistry

Substances

  • abietane
  • Abietanes
  • Phorbols
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Antineoplastic Agents