Association between the prevalence rates of circadian syndrome and testosterone deficiency in US males: data from NHANES (2011-2016)

Yunfei Xiao; Shan Yin; Jianwei Cui; Yunjin Bai; Zhenzhen Yang; Jiahao Wang; Jia Wang

doi:10.3389/fnut.2023.1137668

Association between the prevalence rates of circadian syndrome and testosterone deficiency in US males: data from NHANES (2011-2016)

Front Nutr. 2023 May 9:10:1137668. doi: 10.3389/fnut.2023.1137668. eCollection 2023.

Authors

Yunfei Xiao^#¹, Shan Yin^#², Jianwei Cui^#¹, Yunjin Bai¹, Zhenzhen Yang³, Jiahao Wang¹, Jia Wang¹

Affiliations

¹ Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
² Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
³ Department of Clinical Laboratory, Nanchong Central Hospital, Nanchong, China.

^# Contributed equally.

Abstract

Objective: The objective of this study is to explore the association between the prevalence rates of circadian syndrome (CircS) and testosterone deficiency (TD).

Materials and methods: Cross-sectional analysis was conducted on the basis of the National Health and Nutrition Examination Survey 2011-2016. The target population was males aged ≥20 years old. A total of three multivariable logistic regression models were built to elucidate the association between the prevalence rates of CircS and TD. Interactive and stratified analyses were employed to explore whether some variables can modify the above association. Sensitivity analyses were also conducted to verify the stability of the results with extreme values removed.

Results: A total of 3,436 eligible participants were involved. Multivariable logistic regression in the fully adjusted model suggested the CircS group had a significantly higher prevalence rate of TD compared with the non-CircS group (OR = 2.284, 95%CI 1.569 to 3.323). No significant correlation between the number of CircS components and TD was observed in any of the three models. The interactive and stratified analyses showed the association was more obvious in the population with moderate or vigorous activities. The results were robust after extreme data were excluded.

Conclusion: There is a positive association between the prevalence rates of CircS and TD in US men. The association becomes more obvious owing to moderate or vigorous activities.

Keywords: NHANES; association; circadian syndrome; cross-section; testosterone deficiency.

Grants and funding

This study was supported by the Key Research and Development Projects of the Sichuan Science and Technology Department (grant numbers: 2020YFS0189 and 2022YFS0306) and the project of the Sichuan Provincial Health and Health Commission (grant number: 20PJ064).