Persistence of a SARS-CoV-2 T-cell response in patients with long COVID and lung sequelae after COVID-19

Tamara Cruz; Núria Mendoza; Gema M Lledó; Lídia Perea; Núria Albacar; Alvar Agustí; Jacobo Sellares; Oriol Sibila; Rosa Faner

doi:10.1183/23120541.00020-2023

Persistence of a SARS-CoV-2 T-cell response in patients with long COVID and lung sequelae after COVID-19

ERJ Open Res. 2023 May 9;9(3):00020-2023. doi: 10.1183/23120541.00020-2023. eCollection 2023 May.

Authors

Tamara Cruz^{1

2

3}, Núria Mendoza^{1

3}, Gema M Lledó^{4

3}, Lídia Perea^{1

2}, Núria Albacar^{1

2

5}, Alvar Agustí^{1

2

5}, Jacobo Sellares^{1

2

5}, Oriol Sibila^{1

2

5

6}, Rosa Faner^{1

2

7

6}

Affiliations

¹ Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
² Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Spain.
³ Joint first authors.
⁴ Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Barcelona, Spain.
⁵ Respiratory Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
⁶ Joint senior authors.
⁷ Department of Biomedicine, Immunology Unit, University of Barcelona, Barcelona, Spain.

Abstract

1 year after an acute COVID-19 episode, patients with either lung sequelae or long COVID show a stronger SARS-CoV-2-specific T-cell response than fully recovered individuals, suggesting persistent cell stimulation by residual viral reservoirs https://bit.ly/40bPZm7.