A multifunctionally reversible detector: Photoacoustic and dual-channel fluorescence sensing for SO2/H2O2

Yicai Zhu; Junjun Wang; Yingyong Ni; Qingpeng Rao; Xiaojiao Zhu; Jianhua Yu; Sen Wang; Hongping Zhou

doi:10.1016/j.aca.2023.341181

A multifunctionally reversible detector: Photoacoustic and dual-channel fluorescence sensing for SO₂/H₂O₂

Anal Chim Acta. 2023 Jul 4:1263:341181. doi: 10.1016/j.aca.2023.341181. Epub 2023 Apr 19.

Authors

Yicai Zhu¹, Junjun Wang¹, Yingyong Ni¹, Qingpeng Rao¹, Xiaojiao Zhu¹, Jianhua Yu¹, Sen Wang², Hongping Zhou³

Affiliations

¹ School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Anhui University, Hefei, 230601, PR China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230601, PR China; Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Hefei, 230601, PR China.
² School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Anhui University, Hefei, 230601, PR China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230601, PR China; Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Hefei, 230601, PR China. Electronic address: wangsen@ahu.edu.cn.
³ School of Chemistry and Chemical Engineering, Center of Free Electron Laser & High Magnetic Field, Anhui University, Hefei, 230601, PR China; Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University) Ministry of Education, Hefei, 230601, PR China; Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Hefei, 230601, PR China; Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province, Hefei, 230601, PR China. Electronic address: zhpzhp@263.net.

PMID: 37225328
DOI: 10.1016/j.aca.2023.341181

Abstract

In this work, the phenothiazine fragment with powerful electron-donating ability was specifically selected to construct a multifunctional detector (noted as T1) in double-organelle with near-infrared region I (NIR-I) absorption. The changes of SO₂/H₂O₂ content in mitochondria and lipid droplets were observed through red/green channels respectively, which was due to the reaction between benzopyrylium fragment of T1 and SO₂/H₂O₂ to achieve red/green fluorescence conversion. Additionally, T1 was endowed with photoacoustic properties deriving from NIR-I absorption to reversibly monitor SO₂/H₂O₂in vivo. This work was significant for more accurately deciphering the physiological and pathological processes in living organisms.

Keywords: Donor optimization; Double-organelle; Dual-mode imaging; Near-infrared absorption; SO(2)/H(2)O(2) redox homeostasis.

MeSH terms

Electrons*
Fluorescence
Hydrogen Peroxide*
Lipid Droplets
Mitochondria

Substances

Hydrogen Peroxide