Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties - Synthesis and biological activity

Franz Steppeler; Dominika Iwan; Radosław Gaida; Marta Denel-Bobrowska; Agnieszka B Olejniczak; Elżbieta Wojaczyńska

doi:10.1016/j.biopha.2023.114908

Chiral 2-azabicycloalkanes bearing 1,2,3-triazole, thiourea, and ebselen moieties - Synthesis and biological activity

Biomed Pharmacother. 2023 Aug:164:114908. doi: 10.1016/j.biopha.2023.114908. Epub 2023 May 22.

Authors

Franz Steppeler¹, Dominika Iwan¹, Radosław Gaida¹, Marta Denel-Bobrowska², Agnieszka B Olejniczak², Elżbieta Wojaczyńska³

Affiliations

¹ Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370 Wrocław, Poland.
² Screening Laboratory, Institute of Medical Biology PAS, 106 Lodowa St., 93-232 Łódź, Poland.
³ Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50 370 Wrocław, Poland. Electronic address: elzbieta.wojaczynska@pwr.edu.pl.

PMID: 37224757
DOI: 10.1016/j.biopha.2023.114908

Abstract

2-Azabicycloalkanes: 2-azabicyclo[2.2.1]heptane and 2-azabicyclo[3.2.1]octane were used as a chiral platform for the construction of a set of 1,2,3-triazole, thiourea, and ebselen derivatives. Cytotoxicity and antiviral activity studies revealed the most promising potency for selected thioureas.

Keywords: 1,2,3-triazole; 2-azabicycloalkane; Antiviral activity; Cytotoxicity; Ebselen; Thiourea.

MeSH terms

Antiviral Agents / pharmacology
Organoselenium Compounds* / pharmacology
Structure-Activity Relationship
Thiourea* / pharmacology
Triazoles / pharmacology

Substances

Thiourea
Triazoles
ebselen
Organoselenium Compounds
Antiviral Agents