Simultaneous determination of 24 congeners of 2- and 3-monochloropropanediol esters and 7 congeners of glycidyl esters using direct multi-residue analytical LC-MS/MS methods in various food matrices

Ching-Chang Lee; Bo-Lun Lin; Yi-Wen Huang; Ning-Syuan Hsu; Wei-Hsiang Chang

doi:10.38212/2224-6614.3442

Simultaneous determination of 24 congeners of 2- and 3-monochloropropanediol esters and 7 congeners of glycidyl esters using direct multi-residue analytical LC-MS/MS methods in various food matrices

J Food Drug Anal. 2023 Mar 15;31(1):55-72. doi: 10.38212/2224-6614.3442.

Authors

Ching-Chang Lee^{1

2}, Bo-Lun Lin³, Yi-Wen Huang¹, Ning-Syuan Hsu¹, Wei-Hsiang Chang^{2

3}

Affiliations

¹ Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
² Research Centre of Environmental Trace Toxic Substances, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.
³ Department of Food Safety/Hygiene and Risk Management, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan.

Abstract

Glycidyl esters (GEs) and 2- and 3-monochloropropanediol esters (MCPDEs) are emerging process-generated food contaminants known as possible carcinogens. Herein, a direct method is developed and validated for the first time to simultaneously quantify seven GEs and twenty-four MCPDE congeners of processed foods using liquid chromatography-tandem mass spectrometry in a single sequence without ester cleavage or derivatisation, thereby allowing for the simultaneous analysis of numerous food matrices with high accuracy and precision. Our results show levels of GEs varying from <LOQ to 13486 ng/g, whereas those of MCPDEs range from <LOQ to 12019 ng/g, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, Liquid
Esters
Food*
Tandem Mass Spectrometry*

Substances

monochloropropanediol
Esters

Grants and funding

This work was supported by the Taiwan National Science and Technology Council for financial support: grants 108-2321-B-006-029 and 109-2321-B-006-014.