C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis

Dilek Barutcu Atas; Gizem Kumru Sahin; Şule Şengül; Bülent Kaya; Saime Paydaş; Fatma Alibaz-Oner; Haner Direskeneli; Serhan Tuglular; Ebru Asicioglu

doi:10.31138/mjr.34.1.71

C-Reactive Protein to Albumin Ratio is Associated with Disease Activity in Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis

Mediterr J Rheumatol. 2023 Mar 31;34(1):71-77. doi: 10.31138/mjr.34.1.71. eCollection 2023 Mar.

Authors

Dilek Barutcu Atas¹, Gizem Kumru Sahin², Şule Şengül², Bülent Kaya³, Saime Paydaş³, Fatma Alibaz-Oner⁴, Haner Direskeneli⁴, Serhan Tuglular¹, Ebru Asicioglu¹

Affiliations

¹ Marmara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul, Turkey.
² Ankara University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey.
³ Çukurova University, School of Medicine, Department of Internal Medicine, Division of Nephrology, Adana, Turkey.
⁴ Marmara University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey.

Abstract

Objective/aim: C-reactive protein to albumin ratio (CAR) has recently been recognized as an independent prognostic marker for vasculitides. This study aims to investigate CAR and its relationship with disease activity and damage in prevalent ANCA associated vasculitis (AAV) patients.

Methods: Fifty-one patients with AAV and 42 age-sex-matched healthy controls were enrolled in this cross-sectional study. Birmingham vasculitis score (BVAS) was used to assess vasculitis activity and vasculitis damage index (VDI) to provide information on disease damage.

Results: The median (25^th-75^th) age of the patients were 55 (48-61) years. CAR was significantly higher in AAV patients than controls (1.9±2.7 vs 0.7±0.4; p=0.006). The 75^th percentile of BVAS was defined as high BVAS (BVAS≥5) and ROC curve analysis showed that CAR≥0.98 predicted BVAS≥5 with 70.0% sensitivity and 68.0% specificity (AUC:0.660, CI: 0.482-0.837, p=0.049). When patients with CAR≥0.98 were compared to those without, BVAS [5.0 (3.5-8.0) vs. 2.0 (0-3.25), p<0.001], BVAS≥5 [16 (64.0%) vs 4 (15.4%) patients, p:0.001], VDI [4.0 (2.0-4.0) vs. 2.0 (1.0-3.0), p=0.006], and CAR [1.32 (1.07-3.78) vs. 0.75 (0.60-0.83), p<0.001] were higher whereas albumin [3.8 (3.1-4.3) vs. 4.1 (3.9-4.4) g/dL, p=0.025] and haemoglobin [12.1 (10.4-13.4) vs. 13.0 (12.5-14.2) g/dL, p=0.008] were lower. Multivariate analysis revealed that BVAS [OR(95% CI):1.313 (1.003-1.719), p=0.047] was an independent factor associated with CAR≥0.98 in patients with AAV. Furthermore, correlation analysis showed that CAR significantly correlated with BVAS (r: 0.466, p=0.001).

Conclusion: In this study, we observed that CAR was significantly associated with disease activity in AAV patients and can be used to monitor disease activity.

Keywords: ANCA-associated vasculitis; Birmingham vasculitis activity score; C-reactive protein to albumin ratio; vasculitis damage index.