Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer

Int J Nanomedicine. 2023 May 18:18:2659-2676. doi: 10.2147/IJN.S406415. eCollection 2023.

Abstract

Although various treatments are currently being developed, lung cancer still has a very high mortality rate. Moreover, while various strategies for the diagnosis and treatment of lung cancer are being used in clinical settings, in many cases, lung cancer does not respond to treatment and presents reducing survival rates. Cancer nanotechnology, also known as nanotechnology in cancer, is a relatively new topic of study that brings together scientists from a variety of fields, including chemistry, biology, engineering, and medicine. The use of lipid-based nanocarriers to aid drug distribution has already had a significant impact in several scientific fields. Lipid-based nanocarriers have been demonstrated to help stabilize therapeutic compounds, overcome barriers to cellular and tissue absorption, and improve in vivo drug delivery to specific target areas. For this reason, lipid-based nanocarriers are being actively researched and used for lung cancer treatment and vaccine development. This review discusses the improvements in drug delivery achieved with lipid-based nanocarriers, the obstacles that still exist with in vivo applications, and the current clinical and experimental applications of lipid-based nanocarriers in lung cancer treatment and management.

Keywords: drug delivery system; lipid-based nanocarriers; liposome; lung cancer.

Publication types

  • Review

MeSH terms

  • Drug Delivery Systems
  • Humans
  • Lipids
  • Lung Neoplasms* / drug therapy
  • Nanotechnology

Substances

  • Lipids

Grants and funding

This research was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by MSIT (RS-2023-00207868).