Limitations of X:autosome ratio as a measurement of X-chromosome upregulation

Antonio Lentini; Björn Reinius

doi:10.1016/j.cub.2023.03.059

Limitations of X:autosome ratio as a measurement of X-chromosome upregulation

Curr Biol. 2023 May 22;33(10):R395-R396. doi: 10.1016/j.cub.2023.03.059.

Authors

Antonio Lentini¹, Björn Reinius²

Affiliations

¹ Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Electronic address: antonio.lentini@ki.se.
² Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Electronic address: bjorn.reinius@ki.se.

PMID: 37220727
DOI: 10.1016/j.cub.2023.03.059

Abstract

Lentini and Reinius address issues in interpreting non-allelic gene expression measurements of dosage compensation during murine embryonic development.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Dosage Compensation, Genetic*
Embryonic Development
Female
Mice
Pregnancy
Transcriptional Activation
Up-Regulation
X Chromosome*