We conducted a targeted literature review to understand the determinants of meningococcal serogroups A, C, W, and Y (MenACWY) and meningococcal serogroup B (MenB) vaccination coverage and adherence to vaccination schedules in the USA, and to identify evidence to support improvement of MenACWY and MenB vaccination coverage and adherence in older adolescents. Sources published since 2011 were considered, with sources published since 2015 given preference. Out of 2355 citations screened, 47 (46 studies) were selected for inclusion. Determinants of coverage and adherence ranging from patient-level sociodemographic factors to policy-level factors were identified. Four determinants identified were associated with improved coverage and adherence: (1) well-child, preventive, or vaccination-only appointments (particularly for older adolescents); (2) provider-initiated, provider-driven vaccine recommendations; (3) provider education about meningococcal disease and vaccine recommendations; and (4) state-level school-entry immunization policies. This robust review of the literature sheds light on the continued low MenACWY and MenB vaccination coverage and adherence among older adolescents (16-23 years of age) compared with that of younger adolescents (11-15 years of age) in the USA. The evidence supports a renewed call to action by local and national health authorities and medical organizations urging healthcare professionals to implement a healthcare visit for 16-year-olds and focus on vaccination as a key component of the visit.
Keywords: Adolescents; Invasive meningococcal disease; MenACWY; MenB; Young adults.
Certain meningococcal vaccines are recommended for young people (ages 11–23) in the USA at specific ages. We analyzed scientific studies to understand how many young people in the USA have received meningococcal vaccines and whether they received them at the recommended ages. We found that a low proportion of young people age 16 or older have received appropriate meningococcal vaccination, compared with those under age 16. We looked at reasons why this might be the case and identified actions that could be taken to increase the proportion of young people age 16 or older who receive appropriate meningococcal vaccination. Overall, the information found confirms the importance of encouraging healthcare professionals to establish routine appointments with 16-year-olds, during which they can administer recommended, age-appropriate vaccines.
© 2023. GSK, Inc.