Diterpenoid alkaloids from Delphinium trichophorum

Yang-Li Pu; Ling-Feng Tian; Lin Chen; Meng-Yi Deng; Jiang Xie; Shuai Huang; Xian-Li Zhou

doi:10.1080/10286020.2023.2209564

Diterpenoid alkaloids from Delphinium trichophorum

J Asian Nat Prod Res. 2023 Dec;25(12):1175-1183. doi: 10.1080/10286020.2023.2209564. Epub 2023 May 23.

Authors

Yang-Li Pu^{1

2}, Ling-Feng Tian¹, Lin Chen¹, Meng-Yi Deng^{1

2}, Jiang Xie³, Shuai Huang^{1

2}, Xian-Li Zhou^{1

2}

Affiliations

¹ School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
² Yibin Institute, Southwest Jiaotong University, Yibin 644000, China.
³ The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China.

PMID: 37218665
DOI: 10.1080/10286020.2023.2209564

Abstract

Three new hetisine type C₂₀-diterpenoid alkaloids, named as trichophorines A-C (1-3), were isolated from Delphinium trichophorum, together with nine known alkaloids (4-12). Their structures were elucidated on the basis of spectroscopic data (1D, 2D NMR, single-crystal X-ray, and HR-ESI-MS). All compounds were evaluated for the inhibitory activities against LPS induced NO production in RAW 264.7 macrophage cells, and none of them showed considerable inhibitory activity.

Keywords: Delphinium; Delphinium trichophorum; Ranunculaceae; anti-inflammatory; diterpenoid alkaloids.

MeSH terms

Alkaloids* / chemistry
Alkaloids* / pharmacology
Delphinium* / chemistry
Diterpenes* / chemistry
Diterpenes* / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure

Substances

Alkaloids
Diterpenes