Evaluation and management of pediatric thyroid nodules and thyroid cancer at a single institution after adoption of the American Thyroid Association 2015 guidelines

Leen Matalka; Akm Fazlur Rahman; Sarah Sparks; Brenessa Lindeman; Pallavi Iyer

doi:10.1515/jpem-2022-0334

Evaluation and management of pediatric thyroid nodules and thyroid cancer at a single institution after adoption of the American Thyroid Association 2015 guidelines

J Pediatr Endocrinol Metab. 2023 May 24;36(7):659-666. doi: 10.1515/jpem-2022-0334. Print 2023 Jul 26.

Authors

Leen Matalka¹, Akm Fazlur Rahman², Sarah Sparks³, Brenessa Lindeman⁴, Pallavi Iyer⁵

Affiliations

¹ Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Alabama at Birmingham, Birmingham, USA.
² Department of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.
³ Children's of Alabama, Endocrinology, Birmingham, USA.
⁴ Department of Surgery, Section of Endocrine Surgery, University of Alabama at Birmingham, Birmingham, USA.
⁵ Department of Pediatrics, Division of Endocrinology and Diabetes, Medical College of Wisconsin, Milwaukee, USA.

PMID: 37218509
DOI: 10.1515/jpem-2022-0334

Abstract

Objectives: The study purpose is to correlate clinical findings with rates of differentiated thyroid cancer (DTC) in a cohort of children presenting with thyroid nodules at a single institution since the adoption of the 2015 American Thyroid Association (ATA) Guidelines Task Force on Pediatric Thyroid Cancer.

Methods: Clinical, radiographic, and cytopathologic findings were retrospectively analyzed in a pediatric cohort (≤19 years) identified with ICD-10 codes for thyroid nodules and thyroid cancer from January 2017 until May 2021.

Results: We analyzed 183 patients with thyroid nodules. The mean patient age was 14 years (interquartile range 11-16) with a female (79.2 %) and white Caucasian (78.1 %) predominance. The overall DTC in our pediatric patient cohort was 12.6 % (23 out of 183). Most of the malignant nodules measured from 1-4 cm (65.2 %) with TI-RADS score of ≥4 (69.6 %). Among the fine-needle aspiration results (n=49), the highest frequency of DTC was within the malignant category (16.33 %), followed by suspicious for malignancy (6.12 %), then atypia or follicular lesion of undetermined significance (8.16 %), and lastly follicular lesion or neoplasm and benign with 4.08 % and 2.04 % respectively. Of the forty-four thyroid nodules that underwent surgical intervention, pathology was remarkable for 19 papillary thyroid carcinoma (43.18 %) and 4 follicular thyroid carcinoma (9.09 %).

Conclusions: Based on the analysis of our pediatric cohort in the southeast region at a single institution, adoption of the 2015 ATA guidelines could lead to an increased accuracy in detecting DTC while reducing the number of patients requiring interventions, such as FNA biopsy and/or surgeries. Further, based on our small cohort, it would be reasonable for thyroid nodules 1 cm or less to be monitored clinically with physical exam and ultrasonography, with further therapeutic or diagnostic intervention considered based on concerning features or parental shared decision making.

Keywords: differentiated thyroid cancer; follicular thyroid carcinoma; papillary thyroid carcinoma; pediatric thyroid cancer; pediatric thyroid nodules.

MeSH terms

Adenocarcinoma, Follicular* / diagnosis
Adenocarcinoma, Follicular* / epidemiology
Adenocarcinoma, Follicular* / therapy
Adolescent
Child
Female
Humans
Retrospective Studies
Thyroid Neoplasms* / diagnosis
Thyroid Neoplasms* / epidemiology
Thyroid Neoplasms* / therapy
Thyroid Nodule* / diagnosis
Thyroid Nodule* / epidemiology
Thyroid Nodule* / therapy
Ultrasonography / methods
United States